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When scientists added MOTS-c to cells in a dish, the cells started using more sugar for energy and turned on a key energy sensor called AMPK—until they added folic acid or blocked AMPK, which stopped the effect.
Mice that ate a fatty diet and got daily MOTS-c shots didn’t get as fat as mice that didn’t get the shots—even though they ate the same amount of food.
When mice were given a daily shot of a peptide called MOTS-c, their bodies became better at using sugar for energy and responding to insulin, especially in their muscles.
This drug only helped people whose belly fat went down a lot—so if your belly fat didn’t shrink, we don’t know if it would help your muscles.
Rising IGF-1 levels helped explain some of the muscle growth from the drug, but not all of it—so other factors are also at work.
Even though the drug raised IGF-1, that didn’t predict whether muscles got less fatty—so fat reduction in muscle must be happening through a different pathway.
Even when accounting for changes in growth hormone levels, these muscles still got bigger, meaning the drug works through other pathways too.
Even after accounting for belly fat loss, the muscles along the spine got denser with this drug, meaning it directly improved spinal muscle health.
The drug made the lean parts of the abdominal and rectus muscles denser—meaning they had less fat inside them—more than other muscles, showing it targeted key core muscles.
The muscle growth from this drug wasn’t because belly fat went down—it was more likely due to a rise in a growth-related hormone called IGF-1.
When belly fat went down in these patients, their trunk muscles also got less fatty—suggesting the same process might be cleaning up both types of fat.
The drug made two key core muscles—rectus and psoas—slightly bigger, adding about half a square inch each after six months, while the placebo group didn’t change.
This drug didn’t just make muscles less fatty—it also made them bigger in size, adding about half a square inch of lean muscle in the core area after six months.
For HIV patients with belly fat who responded to this drug, taking tesamorelin for 6 months made their trunk muscles less fatty and more dense, like turning soft muscle into firmer muscle.
In rural Tanzania, moms with no school are much more likely to have babies who miss vaccines — but in cities, whether a mom went to school doesn’t seem to affect vaccine timing.
In rural Tanzania, dads’ education matters a lot for whether their baby gets vaccines on time — but in cities, it doesn’t seem to make much difference.
In both cities and rural areas of Tanzania, about 1 in 6 babies are late or miss their third vaccine shot — even though the reasons are different.
In rural Tanzania, babies who are the fifth or later child in their family are more likely to be late on their vaccines than the first child.
In both cities and rural areas of Tanzania, teenage moms are much more likely to have babies who miss or are late on their vaccines than moms in their mid-20s.
In cities in Tanzania, how much school a mom had doesn’t seem to affect whether her baby gets vaccines on time — but in the countryside, moms with more education are much more likely to get their babies vaccinated on time.
In rural Tanzania, babies born small are actually less likely to miss their vaccines than babies born at a normal weight — the opposite of what’s seen in most other poor countries.
In both cities and rural areas of Tanzania, babies from the poorest families are more likely to be late or miss their vaccines than babies from the richest families.
The injection makes the waist smaller relative to the hips, giving a less 'apple-shaped' body and more 'pear-shaped' proportions.
In rural Tanzania, babies born at home are more likely to be late or miss their vaccines than babies born in hospitals or clinics.