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Over an 8-week training program targeting the elbow flexors, untrained females performed more total resistance exercise volume than untrained males, but both groups showed similar increases in muscle...
In people who have not previously trained, performing 8 weeks of traditional weightlifting exercises for the biceps leads to greater increases in muscle size and strength compared to performing...
Resistance training with moderate weights and many repetitions places less strain on tendons and ligaments while enhancing coordination between nerves and muscles, compared to training with very...
There is no reliable physical evidence to confirm that low-volume, high-intensity training produces better muscle growth than other training methods, despite what some people claim anecdotally.
To stimulate muscle growth, resistance exercises must be performed with adequate duration and precision to activate most of the motor units within the muscle.
The total amount of effective resistance exercise performed for each muscle group in a week is the most important factor in determining how much muscle size increases.
When lifting weights, pushing muscles to complete fatigue does not lead to more muscle growth than training with high volume without reaching failure, because the extra fatigue does not contribute...
Training to muscle failure on a regular basis is associated with higher levels of the stress hormone cortisol and slower recovery of the nervous system, which may limit the amount of muscle gained...
Muscle growth occurs mainly due to the tension placed on muscles and the buildup of metabolic byproducts during exercise, not simply because of how heavy the weights are.
Resistance training with many repetitions leads to an increase in the fluid and energy-storage components of muscle cells, while training with fewer repetitions leads to an increase in the...
Performing resistance exercises with effort close to muscular failure leads to increases in both the contractile proteins and the fluid-filled components of muscle cells.
Performing multiple sets of resistance exercise with sustained tension and fatigue leads to greater activation of muscle fibers and results in an increase in muscle size.
In obese mice, a compound called G49 triggers fat breakdown in white fat tissue through the glucagon receptor, which leads to the release of two signaling molecules—FGF21 and adiponectin—from the...
In obese mice, a drug called G49 boosts calorie burning and activates fat tissue that generates heat, but this effect only occurs if the protein UCP1 is present; without UCP1, the drug fails to...
In obese mice, blocking the breakdown of fat in white fat tissue prevents G49 from triggering increased production of FGF21, ketone bodies, activation of brown fat, and weight loss.
In obese mice, the drug G49 reduces weight and activates fat-burning tissue only when both the glucagon and GLP-1 receptors are active. Blocking either one reduces its effect, but blocking both stops...
After weight-loss surgery in people with severe obesity, two specific blood proteins rise within four weeks, and higher levels of these proteins are linked to greater weight loss one year later. This...
In obese mice, a single injection of a specific drug causes fat cells to break down stored fat, releasing fatty acids into the blood. This triggers a series of metabolic changes in the liver and...
In adults with overweight or obesity, taking 2.4 mg of pemvidutide once a week leads to more weight loss than taking 1.2 mg or 1.8 mg weekly, suggesting that higher doses produce greater effects.
In adults with overweight or obesity, taking weekly pemvidutide at doses up to 2.4 mg for 48 weeks is linked to only small increases in heart rate and no meaningful changes in blood sugar or HbA1c...
In adults with overweight or obesity, a weekly injection of pemvidutide at 2.4 mg for 48 weeks resulted in nearly half of the participants achieving a body mass index below 30 kg/m², which is the...
In adults with excess weight and high blood fats, a weekly injection of pemvidutide for 48 weeks lowers triglycerides, total cholesterol, and LDL cholesterol by specific percentages, even if body...
In adults with overweight or obesity and at least one related health condition, a weekly injection of pemvidutide for 48 weeks resulted in an average weight loss of 15.6%, compared to 2.2% with a...
After metabolic bariatric surgery in people with obesity, levels of two hormones called oxyntomodulin and FGF21 rise within four weeks, and this rise is linked to greater weight loss one year later.