Taking a daily multivitamin for two years makes older adults' brains function as if they are two years younger, based on better memory and thinking skills.
Mechanism
0 studiesTaking 5 grams of creatine daily for six weeks boosts energy storage in brain cells, helping them work better during mental tasks, and this works the same way whether someone eats meat or not.
Taking 5g of creatine daily for six weeks raises phosphocreatine levels in the brain, which helps neurons quickly regenerate ATP when they need energy, supporting thinking and memory functions.
Oral creatine monohydrate is absorbed from the gastrointestinal tract into the bloodstream
Creatine crosses the blood-brain barrier via the creatine transporter (SLC6A8) and is taken up by neurons and glial cells
Intracellular creatine is phosphorylated to phosphocreatine by creatine kinase using ATP
During high neuronal energy demand, phosphocreatine donates its phosphate group to ADP to regenerate ATP
Sustained ATP availability supports neuronal firing, synaptic transmission, and cognitive processing
Evidence from Studies
Supporting (4)
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Taking a daily multivitamin for two years helped older adults think a little better, especially with memory, and the improvement was about as much as what you'd normally see from being two years younger in terms of brain function.
Effects of cocoa extract and a multivitamin on cognitive function: a randomized clinical trial
Taking a daily multivitamin for a few years helped older adults think and remember slightly better — like their brains were almost two years younger. The study found this effect was real and not just by chance.
Taking a daily multivitamin didn't stop older adults from developing memory problems, but those who took it and still had memory issues declined much slower—like their brains aged two years less over the same time.
Effect of multivitamin‐mineral supplementation on change in cognitive function in the COSMOS Clinical subcohort and meta‐analysis of COSMOS cognition studies
Taking a daily multivitamin for two years helped older adults remember things a little better, and their overall thinking may have improved too. This suggests their brains aged a bit slower, though not necessarily by exactly two years as claimed.
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Connected Assertions (1)
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What Would Prove This
Per GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this claim, ordered from strongest to weakest.
Systematic Review and Meta-Analysis of Multivitamin-Mineral Supplementation on Cognitive Aging in Adults Aged 60+ Over Two Years
Population: Adults aged 60 and older; Intervention: Daily multivitamin-mineral supplementation; Comparator: Placebo; Outcomes: Changes in global cognition and episodic memory scores across multiple standardized assessments; Duration: Two years.
Double-Blind, Placebo-Controlled Trial of Daily Multivitamin-Mineral Supplementation on Cognitive Aging in Adults Aged 60+ Over Two Years
Population: Adults aged 60 and older; Intervention: Daily multivitamin-mineral supplement; Comparator: Placebo pill; Outcomes: Pre- and post-intervention scores on global cognition and episodic memory tests; Duration: Two years; Randomization and blinding applied.
Prospective Cohort Study of Multivitamin-Mineral Use and Cognitive Aging Trajectories in Adults Aged 60+ Over Two Years
Population: Adults aged 60 and older; Exposure: Self-reported daily multivitamin-mineral use; Comparator: Non-users; Outcomes: Longitudinal changes in global cognition and episodic memory; Duration: Two years; Adjustment for confounders such as diet, education, and baseline cognition.
Cross-Sectional Analysis of Multivitamin-Mineral Supplementation and Cognitive Test Scores in Adults Aged 60+
Population: Adults aged 60 and older; Exposure: Current multivitamin-mineral supplement use; Outcomes: Single-time-point scores on global cognition and episodic memory tests; No follow-up or temporal sequence assessed.
Case Report of Cognitive Aging Reduction Following Two Years of Daily Multivitamin-Mineral Supplementation in an Individual Aged 65
Population: Single individual aged 65; Intervention: Daily multivitamin-mineral supplementation for two years; Outcomes: Pre- and post-intervention cognitive assessments; No comparator group.
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