The Study
Ingestion of an Oral Hyaluronan Solution Improves Skin Hydration, Wrinkle Reduction, Elasticity, and Skin Roughness: Results of a Clinical Study
This study watched 20 women use a supplement and noticed their skin looked better after 40 days. But we don’t know if the supplement caused it — maybe they drank more water, slept better, or their skin just changed naturally. It’s like noticing your plant looks greener after you talk to it — you can’t be sure talking caused it.
Analysis score
Maximum 22 for a cross-sectional study.
Where the score came from
A small group of women drank a daily liquid containing hyaluronic acid and other nutrients for 40 days to see if it improved their skin.
Where does this study sit?
Reviews of RCTs (Meta-analyses)
Max 100Randomized Trials
Max 90Reviews of Cohort Studies
Max 85Cohort Studies
Max 72Reviews of Case-Control Studies
Max 63Case-Control Studies
Max 58Cross-Sectional & Case Series
Max 50Expert Opinion
Max 522 / 100
Quality score
Snapshots of a population at a single point in time, or descriptions of small groups. Can identify correlations and prevalence, but cannot determine cause and effect.
Key takeaways
Summary
Based on the study abstract and findings.
- 1These changes are noticeable and meaningful — like going from visibly dry, wrinkled skin to noticeably plumper, smoother skin without makeup.
- 2Skin got 24% more hydrated, 13% more elastic, 17% smoother, and wrinkles around the eyes shrank by 26%.
Score breakdown, methodology, conflicts of interest, evidence analysis & raw study data
Publication
Journal
Journal of Evidence-based Complementary & Alternative Medicine
Year
2017
Authors
Imke Göllner, W. Voss, Ulrike von Hehn, Susanne Kammerer
Related Content
Claims (6)
Taking 200 mg of hyaluronic acid by mouth every day increases skin hydration and decreases wrinkle depth in humans.
Women aged 45 to 60 who consumed a specific hyaluronic acid supplement daily for 40 days showed a measurable increase in skin elasticity, with the R2 ratio rising from 0.616 to 0.697, representing a 13.3% improvement according to Cutometer MPA 580 measurements.
Women aged 45 to 60 who consumed a specific hyaluronic acid supplement daily for 40 days showed a 26.4% decrease in the depth of wrinkles around the eyes, as measured by PRIMOS Compact.
Women aged 45 to 60 who consumed a specific hyaluronic acid supplement daily for 40 days showed a 24.4% increase in skin hydration, measured as a rise from 39.32 to 48.87 capacitance units using a Corneometer CM 825.
Women aged 45 to 60 who consumed a specific hyaluronic acid supplement daily for 40 days showed a 16.9% decrease in skin roughness, measured as a reduction in Ra value from 151.48 to 125.94 using PRIMOS Compact.
Women aged 45 to 60 with healthy skin who consume a daily supplement containing hyaluronic acid (≥1 MDa) and other nutrients for 40 days show a 24.4% increase in skin hydration, a 13.3% increase in skin elasticity, a 16.9% reduction in skin roughness, and a 26.4% decrease in periorbital wrinkle depth when measured by instruments.
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.