Taking a daily supplement of 120 mg of hyaluronan for 3 months can make your face skin feel smoother and less rough, especially if you're a healthy Asian adult between 35 and 64 years old.
Claim Language
Language Strength
definitive
Uses definitive language (causes, prevents, cures)
The claim uses 'significantly improves' and 'reduces', which are definitive verbs indicating a direct, measurable, and certain effect, not probabilistic or correlational language.
Context Details
Domain
medicine
Population
human
Subject
Healthy Asian adults aged 35–64
Action
oral ingestion of 120 mg/day hyaluronan for 12 weeks
Target
skin smoothness (SEsm), skin roughness (SEr), and variance (VAR) on the face
Intervention Details
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.
Evidence from Studies
Supporting (1)
Oral Hyaluronan Relieves Wrinkles and Improves Dry Skin: A 12-Week Double-Blinded, Placebo-Controlled Study
This study gave people 120 mg of hyaluronan daily for 12 weeks and found their wrinkles got smaller and skin felt smoother — exactly what the claim says.