Drinking a juice made from tomatoes and soy that contains certain plant compounds is associated with lower levels of specific inflammatory proteins in the bloodstream among adults with obesity.
Mechanism
Synthesis from 1 study
The tomato and soy compounds in the juice get into the bloodstream and quiet down the internal signals in fat and liver cells that normally trigger inflammation. This causes those cells to make fewer inflammatory proteins, which is why those proteins drop in the blood.
Most probable mechanism
When people with obesity drink this juice, the tomato and soy compounds get into their blood and enter fat and liver cells. These compounds block two internal signaling systems that normally tell cells to make inflammatory chemicals. With those signals turned down, the cells produce fewer inflammatory proteins, which then drop in the bloodstream.
Lycopene and isoflavones are absorbed from the gastrointestinal tract and enter systemic circulation
Lycopene and isoflavones inhibit phosphorylation of IκB and activation of ERK in adipose and liver tissues
Inhibition of NF-κB and ERK pathways reduces transcription of pro-inflammatory cytokines including IL-5, IL-12p70, GM-CSF, and TNF-α
Reduced cytokine production leads to lower concentrations of these proteins in the bloodstream
Evidence from Studies
Supporting (1)
Community contributions welcome
Tomato‐Soy Juice Reduces Inflammation and Modulates the Urinary Metabolome in Adults With Obesity
Contradicting (0)
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Gold Standard Evidence Needed
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