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Strong Support
mechanistic
Analysis v1
History

Drinking tomato juice leads to higher levels of certain metabolites in the urine of adults with obesity, which shows that compounds from tomatoes are taken up by the body and broken down.

37
Pro
0
Against

Mechanism

Synthesis from 1 study

How it works

Drinking tomato juice lets your body take in certain plant chemicals from the tomatoes. Your liver changes these chemicals into forms that can dissolve in water, and your kidneys then send them out in your urine. That’s why you see more of these changed chemicals in your pee after drinking tomato...

Most probable mechanism

In Simple Terms

When someone drinks tomato juice, the body takes in certain plant chemicals from the tomatoes through the gut. These chemicals travel to the liver, where they get changed into new forms that can be dissolved in water. These changed forms then get filtered out by the kidneys and show up in urine.

Causal chain
1

Tomato-derived flavonoids (e.g., naringenin) and hydroxycinnamic acids are absorbed across the intestinal epithelium into the bloodstream

Supported by evidence
Tomato‐Soy Juice Reduces Inflammation and Modulate...
which leads to
2

These compounds are transported to the liver and undergo phase II metabolism, including glucuronidation and other conjugation reactions

Supported by evidence
Tomato‐Soy Juice Reduces Inflammation and Modulate...
which leads to
3

The resulting glucuronide and other catabolite conjugates are excreted via the kidneys into urine

Supported by evidence
Tomato‐Soy Juice Reduces Inflammation and Modulate...

Evidence from Studies

Supporting (1)

37

Community contributions welcome

37

Tomato‐Soy Juice Reduces Inflammation and Modulates the Urinary Metabolome in Adults With Obesity

Randomized Controlled Trial
Human
2026 Mar

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

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Source Study

Tomato‐Soy Juice Reduces Inflammation and Modulates the Urinary Metabolome in Adults With Obesity

Score: 37
DOI: 10.1002/mnfr.70420

Similar Assertions

Drinking tomato-soy juice is associated with lower levels of certain fat-related compounds in the urine of adults with obesity, which may indicate a change in how the body processes fatty acids, regardless of the presence of lycopene or soy isoflavones.

37
0
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Drinking tomato-soy juice increases the amount of specific breakdown products from soy in the urine of adults with obesity, showing that the body metabolizes and absorbs soy compounds effectively.

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77%

In people with obesity, a juice made from tomatoes and soy reduces inflammation similarly to a tomato juice with fewer plant compounds, suggesting that lycopene and soy isoflavones are not the main reasons for the reduction in inflammatory markers.

37
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75%

Drinking tomato-soy juice daily for four weeks, which contains 54 mg of lycopene and 189.9 mg of soy isoflavones, increases lycopene in the blood and lowers levels of specific inflammatory signaling molecules in adults with obesity.

37
0
72%

Drinking a juice made from tomatoes and soy that contains certain plant compounds is associated with lower levels of specific inflammatory proteins in the bloodstream among adults with obesity.

37
0
70%