Strong Support
mechanistic
Analysis v1
History

Drinking tomato-soy juice increases the amount of specific breakdown products from soy in the urine of adults with obesity, showing that the body metabolizes and absorbs soy compounds effectively.

37
Pro
0
Against

Mechanism

Synthesis from 1 study

How it works

The soy in the juice gets broken down by gut bacteria into smaller pieces, then the liver wraps them in water-friendly molecules so the kidneys can easily flush them out in urine. The urine tests show these exact wrapped molecules increased, proving the whole process happened.

Most probable mechanism

In Simple Terms

When people drink tomato-soy juice, the soy parts get absorbed from the gut into the blood. Then, bacteria in the gut break down these soy parts into smaller molecules, which the liver changes into water-soluble forms. These changed molecules are filtered by the kidneys and flushed out in urine.

Causal chain
1

Soy isoflavones are absorbed from the gastrointestinal tract into systemic circulation

which leads to
2

Gut microbiota metabolize absorbed isoflavones into compounds such as O-desmethylangolensin and ethylphenol precursors

which leads to
3

Liver enzymes conjugate these microbial metabolites with glucuronic acid or sulfate groups to increase water solubility

which leads to
4

Conjugated metabolites are filtered by the kidneys and excreted in urine

Evidence from Studies

Supporting (1)

37

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Contradicting (0)

0

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

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