Drinking tomato-soy juice is associated with lower levels of certain fat-related compounds in the urine of adults with obesity, which may indicate a change in how the body processes fatty acids,...
Mechanism
Synthesis from 1 study
The juice helps the body burn fat more completely in its energy factories, so fewer incomplete fat pieces end up in the urine. This effect seems to come from the whole mixture, not just the tomato or soy parts alone.
Most probable mechanism
The juice contains compounds that help the body's energy factories (mitochondria) burn fat more efficiently, so fewer partially burned fat pieces build up in the urine.
Bioactive compounds from tomato and soy are absorbed from the gastrointestinal tract and enter systemic circulation
These compounds activate peroxisome proliferator-activated receptor alpha (PPARα) in liver and muscle tissues
PPARα activation increases expression of enzymes involved in mitochondrial beta-oxidation, including acyl-CoA dehydrogenases and carnitine palmitoyltransferase I
Enhanced beta-oxidation reduces accumulation of medium-chain acylcarnitines by promoting complete fatty acid breakdown to acetyl-CoA
Less supported by current evidence, but not ruled out
The juice may signal fat cells to hold onto their fat instead of releasing it, so less fat is available to be partially burned and turned into the compounds found in urine.
Bioactive compounds reduce adipose tissue lipolysis via suppression of hormone-sensitive lipase activity
Reduced free fatty acid flux to the liver decreases mitochondrial fatty acid overload and incomplete oxidation
Lower substrate availability reduces medium-chain acylcarnitine synthesis as a byproduct of incomplete beta-oxidation
Evidence from Studies
Supporting (1)
Community contributions welcome
Tomato‐Soy Juice Reduces Inflammation and Modulates the Urinary Metabolome in Adults With Obesity
Contradicting (0)
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