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Strong Support
causal
Analysis v1
History

Drinking tomato-soy juice daily for four weeks, which contains 54 mg of lycopene and 189.9 mg of soy isoflavones, increases lycopene in the blood and lowers levels of specific inflammatory signaling...

37
Pro
0
Against

Mechanism

Synthesis from 1 study

How it works

The tomato-soy juice delivers compounds that enter your blood and quiet down inflammation signals inside your fat and liver cells. This stops those cells from producing too many inflammation-causing molecules, which is why levels of those molecules drop in your blood.

Most probable mechanism

In Simple Terms

When you drink this tomato-soy juice, the lycopene and soy compounds get into your blood and enter your fat and liver cells. These compounds block certain chemical signals inside the cells that normally tell the body to make inflammation-causing molecules. As a result, fewer of those molecules are released into the bloodstream, which lowers overall inflammation.

Causal chain
1

Lycopene and soy isoflavones are absorbed from the gastrointestinal tract and enter systemic circulation

Verified by multiple studies
Tomato‐Soy Juice Reduces Inflammation and Modulate...
which leads to
2

Lycopene and isoflavones inhibit phosphorylation of IκB and activation of ERK in adipose and liver tissues

Supported by evidence
Tomato‐Soy Juice Reduces Inflammation and Modulate...
which leads to
3

Inhibition of NF-κB and ERK signaling reduces transcription of pro-inflammatory cytokines including IL-5, IL-12p70, GM-CSF, and TNF-α

Verified by multiple studies
Tomato‐Soy Juice Reduces Inflammation and Modulate...

Evidence from Studies

Supporting (1)

37

Community contributions welcome

37

Tomato‐Soy Juice Reduces Inflammation and Modulates the Urinary Metabolome in Adults With Obesity

Randomized Controlled Trial
Human
2026 Mar

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

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Source Study

Tomato‐Soy Juice Reduces Inflammation and Modulates the Urinary Metabolome in Adults With Obesity

Score: 37
DOI: 10.1002/mnfr.70420

Similar Assertions

In people with obesity, a juice made from tomatoes and soy reduces inflammation similarly to a tomato juice with fewer plant compounds, suggesting that lycopene and soy isoflavones are not the main reasons for the reduction in inflammatory markers.

37
0
90%

Drinking a juice made from tomatoes and soy that contains certain plant compounds is associated with lower levels of specific inflammatory proteins in the bloodstream among adults with obesity.

37
0
79%

Drinking tomato-soy juice increases the amount of specific breakdown products from soy in the urine of adults with obesity, showing that the body metabolizes and absorbs soy compounds effectively.

37
0
74%

Drinking tomato-soy juice is associated with lower levels of certain fat-related compounds in the urine of adults with obesity, which may indicate a change in how the body processes fatty acids, regardless of the presence of lycopene or soy isoflavones.

37
0
73%

Drinking tomato juice leads to higher levels of certain metabolites in the urine of adults with obesity, which shows that compounds from tomatoes are taken up by the body and broken down.

37
0
72%