A compound called 17-α-estradiol was found to extend lifespan in tests done at three different research centers, and all three studies showed similar results even though they were done 5 years apart.

13

Pro

0

Against

Evidence from Studies

Supporting (1)

13

Community contributions welcome

13

17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex

Cohort Study

Animal

2021 May

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex

Score: 13

DOI: 10.1111/acel.13328

Similar Assertions

A compound called 17-alpha-estradiol was tested in three different labs, and all three found it extended lifespan by similar amounts.

0

93%

Scientists fed old male mice a special chemical called 17-α-estradiol and found they lived about 19% longer than mice that didn't get the chemical.

13

0

83%

Giving male mice a special compound called 17-α-estradiol when they were middle-aged (16 months) helped them live about 7% longer, specifically extending their maximum lifespan.

13

0

83%

A special form of estrogen called 17-alpha-estradiol helped male mice live longer, but female mice given the same amount didn't get any lifespan benefit.

13

0

82%

A special form of estrogen given to mice at a specific dose helped male mice live longer, but didn't have the same effect on female mice.

0

13

80%