A compound called 17-alpha-estradiol was tested in three different labs, and all three found it extended lifespan by similar amounts.

Evidence from Studies

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No supporting evidence found

Contradicting (1)

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17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex

Cohort Study

Animal

2021 May

The study tests the same drug (17-alpha-estradiol) but only shows results from one location, not the three different universities mentioned in the claim. There's no evidence that the same experiment was done at University of Texas, University of Michigan, and The Jackson Laboratory with consistent results.

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex

Score: 13

DOI: 10.1111/acel.13328

Similar Assertions

A compound called 17-α-estradiol was found to extend lifespan in tests done at three different research centers, and all three studies showed similar results even though they were done 5 years apart.

13

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93%

Giving male mice a special compound called 17-α-estradiol when they were middle-aged (16 months) helped them live about 7% longer, specifically extending their maximum lifespan.

13

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80%

Scientists fed old male mice a special chemical called 17-α-estradiol and found they lived about 19% longer than mice that didn't get the chemical.

13

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78%

A special form of estrogen called 17-alpha-estradiol helped male mice live longer, but female mice given the same amount didn't get any lifespan benefit.

13

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78%

Scientists gave male mice a compound called 17-alpha-estradiol at different ages and found that mice treated at 16 months lived about 7% longer than untreated mice, but mice treated later at 20 months only lived about 5% longer - and that result might just be due to chance.

13

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76%