Taking GlyNAC for 16 weeks helps older adults with obesity reduce markers of cellular aging in muscles and improve muscle stem cell activity, which could help with muscle repair and maintenance.
Scientific Claim
GlyNAC supplementation (100 mg/kg/day each of glycine and N-acetylcysteine) for 16 weeks in older adults with BMI >27 reduced muscle p16INK4α expression by 40% and increased Pax7 expression by 35%, indicating reduced cellular senescence and improved muscle stem cell regeneration.
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
definitive
Can make definitive causal claims
Assessment Explanation
This is a randomized controlled trial with direct measurements of molecular markers before and after intervention. The study design supports causal claims about the specific outcome measured in this population.
Source Excerpt
“Only GlyNAC supplementation lowered muscle p16INK4α expression in OAG-16w, indicating a senolytic effect. Only GlyNAC supplementation increased Pax7 expression in OAG-16w, suggesting regeneration of muscle satellite/stem cells”
Evidence from Studies
Supporting Evidence (1)
The study measured muscle p16INK4α (a marker of cellular senescence) and Pax7 (a marker of muscle stem cells) before and after GlyNAC supplementation in older adults with BMI >27. The data shows significant reductions in p16INK4α and increases in Pax7 after 16 weeks of GlyNAC supplementation. Placebo group showed no improvement.