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Even if middle-aged people have high cholesterol, nearly half of them might still have completely clean heart arteries, and over a third show no signs of plaque buildup — so high cholesterol doesn’t...
Even if someone has very high 'bad' cholesterol, more than half of middle-aged people with no symptoms still show no signs of heart artery buildup — meaning their bodies might be naturally protecting...
If a middle-aged person has very high 'bad' cholesterol but feels fine, they’re more than 2.6 times as likely to have early signs of heart artery buildup — even if everything else about their health...
High levels of PCSK9 in the blood are linked to higher heart attack risk and more dangerous plaque in arteries, even if cholesterol is controlled.
A type of cholesterol drug called PCSK9 inhibitors might help prevent blood clots by calming down overactive platelets, and this effect has been seen in people with a genetic form of high cholesterol...
PCSK9 doesn't just affect cholesterol—it also turns on inflammation switches in immune cells, which can damage blood vessels even if cholesterol is normal.
PCSK9 drugs don't just lower cholesterol—they can actually help shrink dangerous plaque buildup in heart arteries over time.
Drugs like alirocumab and evolocumab can lower bad cholesterol by more than half in people with a genetic cholesterol problem, and they keep working well for over a year with regular use.
People taking a cholesterol drug called evolocumab had almost twice as many heart failure deaths as those on a dummy pill in one big study, but this wasn’t mentioned in the main report—so scientists...
A second look at heart death data from a major drug trial found more heart-related deaths in the treatment group than were first reported, while the placebo group had fewer — suggesting the original...
People with heart disease who took a drug called evolocumab had more heart-related deaths than those who took a dummy pill, according to a reanalysis of a major study — but the difference wasn’t...
Taking cholesterol drugs called evolocumab or alirocumab doesn’t seem to raise your risk of bleeding in the brain — the numbers show it’s about the same as not taking them.
Taking certain cholesterol drugs called evolocumab or alirocumab may help lower the chance of heart problems, whether you've already had heart issues or are just trying to prevent them.
Taking certain cholesterol drugs called evolocumab or alirocumab might lower the chance of having a stroke, whether you've already had heart problems or not.
Oral PCSK9 inhibitors can achieve approximately 58% reduction in LDL cholesterol, offering a non-injectable alternative to monoclonal antibody...
Ezetimibe reduces LDL cholesterol by inhibiting intestinal cholesterol absorption and is underutilized despite its efficacy, safety, and low cost.
Subclinical atherosclerosis develops in a linear relationship with LDL cholesterol levels, with plaque accumulation beginning at approximately 50–60...
Adding a drug called evolocumab to cholesterol-lowering statins can lower the chances of serious heart problems by 20% in people who already have heart disease.
Monoclonal antibody inhibition of PCSK9 with evolocumab reduces LDL cholesterol by approximately 81% in patients already on statin therapy.
PCSK9 promotes the degradation of hepatic LDL receptors, thereby reducing the liver's capacity to clear LDL cholesterol from the bloodstream.
Loss-of-function mutations in the PCSK9 gene are associated with lifelong lower LDL cholesterol and a substantially reduced risk of coronary heart...
Older men are more likely to use sarcastic or self-critical humour, while older women are more likely to use friendly and uplifting humour to cope with stress.
When older adults exercise together, it can help them feel less lonely — and part of why this works is because they use upbeat, friendly humor to connect with each other.
Older adults who exercise or play sports with friends tend to feel less lonely — and this is true both for those doing it now and those who did it in the past.