Health Claims

Female mice on a weekly rapamycin dose ran more and faster than those on a more frequent dose or no drug, but despite running more, they didn’t lose more fat or get healthier metabolically.

In female mice that exercised with weighted wheels for 8 weeks, taking the drug rapamycin — even just once a week — made their blood sugar control worse, but doing it less often caused fewer problems.

Even when taking rapamycin, female mice still get stronger and fitter from using a weighted exercise wheel — the drug doesn't stop their workout gains.

Some new medicines that aim to slow aging might help older people keep stronger muscles, but we don’t have enough proof yet to say for sure if they work.

Taking medicine and doing exercise together might help older people, especially those losing muscle, feel stronger and live better — but we don’t have enough proof yet.

Some medicines and supplements might help older people keep or build muscle, especially if they also exercise — but we’re not totally sure yet if combining them works better than just doing one or...

Giving female mice a certain drug (rapamycin) once a week helps them run more on their own compared to giving it more often or not at all.

In female mice that run a lot, taking rapamycin frequently stops them from losing fat — even though exercise usually helps them slim down.

In female mice that run with added weight, taking a drug called rapamycin makes it harder for their bodies to handle sugar — but doing it less often doesn't hurt as much, so spacing out doses might...

In female mice that run with added weight, giving rapamycin three times a week blocks a key muscle growth signal, but giving it just once a week doesn’t keep that block going — so how often you dose...

In female mice that exercised a lot for 8 weeks, taking rapamycin — a drug that affects aging — either once a week or three times a week didn’t stop them from getting stronger or improving their...

Older male mice have bigger changes in muscle chemicals after taking rapamycin than older female mice, suggesting their bodies respond differently to this drug as they age.

Older mice with overactive mTORC1 had higher levels of certain muscle-related amino acid processes after taking rapamycin, which might help muscles handle stress and stay healthy.

In older mice with overactive muscle metabolism, giving them a drug called rapamycin changes the types of fats in their muscles — some go up, some go down — which might mean the drug helps reset how...

Rapamycin helps 'rejuvenate' some muscles in old mice but not others—turns out, it depends on the muscle and how connected it is to nerves. In muscles that are more affected by aging, the drug might...

As mice get older, a key cellular switch called mTORC1 in their muscles turns down genes that keep muscle structure strong, turns up genes linked to inflammation, and flips on signals seen when...

As mice get older, the places where nerves connect to muscles show big changes in genes tied to inflammation and tissue breakdown — especially in a key area called the neuromuscular junction — which...

Turning on a certain signal in mouse muscles makes them age faster, causing nerve and muscle problems like those seen in old age — but this can be reversed with a drug called rapamycin.

Giving older mice a drug called rapamycin helps keep their muscles strong and working well as they age, especially in some muscles but not others.

In kids who got a kidney transplant and are on a certain anti-rejection drug combo, taking more or less of one drug (mycophenolic acid) doesn’t change how the body handles another drug (sirolimus).

For kids who've had a kidney transplant and are taking a drug called sirolimus (but not certain other drugs), checking the lowest level of the drug in their blood helps doctors figure out how much of...

Kids who got a kidney transplant and are taking a drug called sirolimus clear it from their bodies faster than adults do, especially in the first few months after surgery.

The tools we use to measure rapamycin in the fluid around the brain aren't sensitive enough to catch the tiny amounts that actually get there, so we can't tell if it's really crossing into the brain...

People with early Alzheimer’s who take 7 mg of rapamycin every week seem to have low levels of the drug in their blood before their next dose—so low that it probably won’t weaken their immune system.