Browse evidence-based analysis of health-related claims and assertions
MOTS-c treatment in obese mice reduced the activity of a liver enzyme called Por by half, which may affect fat metabolism.
Quantitative
MOTS-c injections in obese mice lowered sebacate, a dicarboxylic acid, by 42% compared to untreated mice.
Obese mice given MOTS-c had lower levels of suberate, a dicarboxylic acid, by 40% compared to untreated mice.
MOTS-c injections in obese mice reduced a type of fat molecule called 2-oleoylglycerol by about 32% compared to untreated mice.
Obese mice treated with MOTS-c had lower levels of a specific sphingolipid called palmitoyl sphingomyelin, which is associated with insulin resistance.
MOTS-c injections in obese mice lowered a specific blood fat molecule called sphingosine 1-phosphate by about 14% compared to untreated mice.
Obese mice given MOTS-c injections for three days had lower blood sugar levels than mice that didn't receive the treatment.
When PGC-1α is increased in muscle cells, they break down a specific type of fat (lignoceric acid) more efficiently using both peroxisomes and mitochondria. This finding is from the abstract summary - full study details were not available
Descriptive
Increasing PGC-1α in muscle cells leads to higher levels of mRNA for breaking down fats in peroxisomes. This finding is from the abstract summary - full study details were not available
When muscle cells in a lab have more PGC-1α protein, they show higher levels of PMP70, which is a protein involved in peroxisome function. This finding is from the abstract summary - full study details were not available
In immobilized mice, higher levels of MOTS-c in the muscles were linked to better muscle mass retention.
Correlational
MOTS-c lowered levels of myostatin, a protein that inhibits muscle growth, in the muscles of immobilized mice.
MOTS-c reduced the amount of fatty acids in the muscles of immobilized mice, which may prevent harmful fat buildup.
MOTS-c increased the production of a protein called ANGPTL4 in the muscles of immobilized mice, which helps control fat uptake into muscle tissue.
Mechanistic
MOTS-c changed the activity of genes related to fat metabolism and PPAR pathways in the muscles of immobilized mice, which may affect how fat builds up in muscle tissue.
MOTS-c reduced levels of several inflammatory proteins in the blood of immobilized mice, which may help reduce muscle damage.
MOTS-c helped maintain higher activity levels of key muscle signaling proteins (AKT, FOXO1, FOXO3a) in immobilized mice, which are important for muscle health.
When mice had their legs immobilized for 8 days, giving them MOTS-c helped their muscles lose less weight (5% instead of 15%) compared to mice that didn't get the treatment.
For people with uncomplicated type 2 diabetes, sufficient oxygen in their muscles is linked to better energy recovery after exercise.
Higher blood sugar levels in obese adults with type 2 diabetes are linked to how well their muscles produce energy during exercise recovery.
Extra oxygen helps obese adults with type 2 diabetes produce muscle energy more quickly after exercise, as measured by oxidative phosphorylation rates.
Giving extra oxygen to obese adults with type 2 diabetes helps their muscles recover energy faster after exercise, as measured by quicker ADP depletion.
Obese adults with type 2 diabetes have slower muscle energy production rates after exercise compared to those without diabetes, as measured by oxidative phosphorylation.
People with type 2 diabetes who are sedentary and obese take longer to recover their muscle energy levels after exercise compared to obese people without diabetes, as measured by how quickly their muscles use up ADP.