Browse evidence-based analysis of health-related claims and assertions
A protein called LAMP2A, which is involved in cellular cleanup processes, was found at similar levels in people having a heart attack and those with stable heart disease, and its levels didn't relate to PLIN2 protein levels.
Descriptive
The types and amounts of fats inside blood cells were similar between people having a heart attack and those with stable heart disease, even though the PLIN2 protein levels were different between these groups.
People having a heart attack have higher levels of harmful molecules called ROS/RNS in their blood compared to people with stable heart disease, which might be related to the heart attack process.
In people with heart disease, older patients tend to have higher levels of PLIN2 protein in their blood cells, and this relationship is stronger in those with stable heart disease than in those having a heart attack.
Correlational
In people with stable heart disease, when the proteasome (a cellular cleanup system) is more active, there's less PLIN2 protein present, but this relationship doesn't hold for people having a heart attack.
In people having a heart attack called STEMI, the amount of a protein called PLIN2 in certain blood cells is higher than in people with stable heart disease, which might be related to why their heart attack happened.
Mice that got the supplement were more responsive to insulin compared to mice that didn't get it.
Quantitative
Mice that got the supplement had less fat buildup in their brown fat compared to mice that didn't get it.
Mice that got the supplement had higher levels of genes that help burn fat in their livers compared to mice that didn't get it.
Mice that got the supplement had much lower levels of genes involved in fat uptake and storage in their livers compared to mice that didn't get it.
Mice that got the supplement had higher levels of genes that help burn calories in their brown fat compared to mice that didn't get it.
Mice that got the supplement had lower levels of a gene that helps store fat in their livers compared to mice that didn't get it.
Mice that got the supplement had much lower levels of fat and cholesterol in their livers compared to mice that didn't get it.
Mice that got the supplement had smaller livers compared to mice that didn't get it.
Mice that got the supplement had much lower levels of insulin in their blood compared to mice that didn't get it.
Mice that got the supplement were better able to handle sugar in their blood after eating.
Mice that got the supplement had higher levels of a hormone that helps regulate metabolism in their fat tissue.
Mice that got the supplement had fewer immune cells in their fat tissue compared to mice that didn't get it.
The fat cells in mice that got the supplement were about 30% smaller than in mice that didn't get it.
Mice that got the supplement had smaller fat deposits around their organs and under their skin compared to mice that didn't get it.
Mice that got the supplement had about half as much body fat as mice that didn't get it, even when both groups ate the same high-fat diet.
Giving mice a special supplement in their water for 11 weeks helped them stay lighter when eating a high-fat diet, even though they ate the same amount of food.
For some stroke patients, NAC treatment actually made some blood markers related to oxidative stress worse, while improving others.
When comparing stroke patients who received NAC to those who didn't, only one blood marker related to oxidative stress showed a significant difference between the groups.